The cardiac muscle duplex as a method to study myocardial heterogeneity

نویسندگان

  • O. Solovyova
  • L.B. Katsnelson
  • P.V. Konovalov
  • A.G. Kursanov
  • N.A. Vikulova
  • P. Kohl
  • V.S. Markhasin
چکیده

This paper reviews the development and application of paired muscle preparations, called duplex, for the investigation of mechanisms and consequences of intra-myocardial electro-mechanical heterogeneity. We illustrate the utility of the underlying combined experimental and computational approach for conceptual development and integration of basic science insight with clinically relevant settings, using previously published and new data. Directions for further study are identified.

برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید

ثبت نام

اگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید

منابع مشابه

Effect of Eight Weeks of Aerobic Training on Some Myocardial Fibrosis Indices in Cardiac Muscle of Diabetic Rats

Background. Myocardial fibrosis is identified as a major side effect of Diabetes Mellitus on the heart. Some bio-markers including the ratio of matrix metalloproteinases and their inhibitors in collagen synthesis and collagen degradation are clinically useful in the diagnosis and identification of myocardial fibrosis. In addition, regular aerobic exercise training is one of the major and non-ph...

متن کامل

An Aptamer-based Biosensor for Troponin I Detection in Diagnosis of Myocardial Infarction

Background: Acute myocardial infarction (MI) accounts for one third of deaths. Cardiac troponin I (TnI) is a reliable biomarker of cardiac muscle tissue injury and is employed in the early diagnosis of MI.Objectives: In this study, a molecular method is introduced to early diagnosis of MI by rapid detection of TnI.Materials and Methods: The detection method was based on electrochemical aptasens...

متن کامل

Hybrid duplex: a novel method to study the contractile function of heterogeneous myocardium.

In an earlier study, we experimentally mimicked the effects of mechanical interaction between different regions of the ventricular wall by allowing pairs of independently maintained cardiac muscle fibers to interact mechanically in series or in parallel. This simple physiological model of heterogeneous myocardium, which has been termed "duplex," has provided new insight into basic effects of ca...

متن کامل

Detection of Cardiac Artery Disease by Using the DCAD (b) Module

Introduction: In patients with cardiac artery disease, a myocardial perfusion scan, which is a non-invasive method, is utilized. This study is conducted to develop an advantageous software applicable to quantitative myocardial SPECT perfusion. Material and Methods: Each cross-section of the left ventricle was segmented by applying a fuzzy clustering method. After obtaining the myocardial skelet...

متن کامل

Effect of Progressive Muscle Relaxation on Hypertension of Aged With Myocardial Infarction

Objectives: Hypertension is a third cause of mortality in the world and also has great cost of treatment for patients. Use of non pharmacologic methods similar as progressive muscle relaxation can reduce blood pressure and its complication such as myocardial infarction (MI). The study purpose determine conducted to the effect of progressive muscle relaxation on hypertensive patients with myocar...

متن کامل

ذخیره در منابع من


  با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید

برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید

ثبت نام

اگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید

عنوان ژورنال:

دوره 115  شماره 

صفحات  -

تاریخ انتشار 2014